C8B
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Involvement in disease
Complement component 8 deficiency, 2
C8D2
A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Post-translational modifications
N-glycosylated; contains one or two bound glycans. Not O-glycosylated.
Sequence Similarities
Belongs to the complement C6/C7/C8/C9 family.
Cellular localization
- Secreted
Alternative names
Complement component C8 beta chain, Complement component 8 subunit beta, C8B