C8G

Function

C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

Sequence Similarities

Belongs to the calycin superfamily. Lipocalin family.

Cellular localization

• Secreted

Alternative names

Complement component C8 gamma chain, C8G

Database links

swissprot:P07360 omim:120960 swissprot:P07357 swissprot:P07358 entrezGene:733 entrezGene:732 entrezGene:731 omim:120950 omim:120930