C9orf78
Function
Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828).
Sequence Similarities
Belongs to the TLS1 family.
Cellular localization
- Nucleus
- Chromosome
- Centromere
- Dispersed throughout the nucleus during interphase (PubMed:35167828). Colocalizes with microtubule attachment sites at centromeres following mitotic checkpoint activation (PubMed:35167828).
Alternative names
HCA59, C9orf78, Splicing factor C9orf78, Hepatocellular carcinoma-associated antigen 59