CABC1_PROVU
Domain
Consists of three domains. The middle domain contains the catalytic site in a wide-open cleft.
Function
Endolytic, broad-specificity glycosaminoglycan lyase, which degrades the polysaccharides chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate, dermatan sulfate and to a lesser extent hyaluronan, by beta-elimination of 1,4-hexosaminidic bond to unsaturated tetrasaccharides and disaccharides. Is not active against keratan sulfate, heparan sulfate, and heparin. Is able to promote functional recovery in the injured central nervous system (CNS), via its role in the disruption of the normal organization of the extracellular matrix (ECM).
Sequence Similarities
Belongs to the polysaccharide lyase 8 family.
Cellular localization
- Periplasm
Alternative names
Chondroitin sulfate ABC endolyase, Chondroitin ABC endoeliminase, Chondroitin ABC lyase I, Chondroitin sulfate ABC lyase I, Chondroitinase ABC I, Endochondroitinase ABC, ChS ABC lyase I, cABC I