CABP1
Domain
EF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium cooperatively and EF-2 binds neither calcium nor magnesium.
Function
Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs) (PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed:15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity).
Post-translational modifications
Phosphorylated. The phosphorylation regulates the activity.
Tissue Specificity
Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cytoplasm
- Perinuclear region
- Cell membrane
- Lipid-anchor
- Cytoplasmic side
- Golgi apparatus
- Postsynaptic density
- L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane.
- Isoform L-CaBP1
- Cytoplasm
- Cytoskeleton
- L-CaBP1 is associated most likely with the cytoskeletal structures.
- Isoform S-CaBP1
- Cytoplasm
- Cell cortex
- Cell membrane
- Lipid-anchor
- S-CaBP1 is localized at or near the plasma membrane.
Alternative names
Calcium-binding protein 1, CaBP1, Calbrain, Caldendrin, CABP1