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Cacna1c

GeneName

CACNA1C

Summary

CACNA1C, also known as RBC or MBC, is a 249 kDa protein that forms part of the L-type voltage-gated calcium channel complex. It is predominantly expressed in cardiac and neuronal tissues, where it plays a critical role in calcium ion transport across the plasma membrane. This protein is localised to various subcellular compartments, including the plasma membrane, postsynaptic density, and T-tubules. CACNA1C is essential for the generation and propagation of action potentials in cardiac muscle cells, facilitating calcium influx that triggers muscle contraction and regulates heart rate. Additionally, it is involved in processes such as cardiac conduction and embryonic development.

Importance

CACNA1C is relevant to: - Cardiac health, as it directly influences heart rhythm and contraction strength, making it a target for therapies in arrhythmias and heart failure - Neurological research, due to its role in neuronal excitability and synaptic transmission - Developmental biology, as it is implicated in the morphogenesis of structures such as the embryonic forelimb - Calcium signalling pathways, which are crucial for various cellular functions and have implications in diseases like hypertension and heart disease

Top Products

For researchers investigating CACNA1C, we highly recommend the top-selling recombinant antibody, Anti-CACNA1C antibody [S57] (ab84814). This antibody has been validated for use in several applications, including Western blotting (WB), immunocytochemistry (ICC), immunohistochemistry (IHC), and flow cytometry (FC), making it a versatile tool for your research needs. With 36 citations, it is well-regarded in the scientific community, reflecting its reliability and effectiveness in CACNA1C detection. This product is an excellent choice for those seeking the consistency and performance that recombinant antibodies offer.

Abcam Product Citation Summary

The data indicates that the Abcam antibody ab84814 was employed to study the CACNA1C gene in rats, specifically focusing on the effects of miR-711 on gene expression. This suggests a potential role of miR-711 in regulating CACNA1C, which may have implications for understanding its function in various biological contexts.

Abcam Product Citation Table

Product Code
Species
Application
Study Context
PMID
ab84814
Rat
WB, ICC-IF
Effects of miR-711 on gene expression
32308692

Domain

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel.

Function

Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:14609949, PubMed:18586882, PubMed:21216955, PubMed:25368181, PubMed:28119464, PubMed:10973973). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:21216955). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:14609949, PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).

Post-translational modifications

Phosphorylation by PKA at Ser-1897 activates the channel (PubMed:28119464). Elevated levels of blood glucose lead to increased phosphorylation by PKA.

Sequence Similarities

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.

Tissue Specificity

Detected in embryonic heart (PubMed:10973973, PubMed:21216955). Detected in retina in rod bipolar cells (PubMed:18586882). Detected in tibialis artery (at protein level) (PubMed:14609949). Detected in smooth muscle cells from tibialis artery and in mesenteric artery (PubMed:14609949). High expression in heart, followed by brain and spinal cord (PubMed:1385406).

Cellular localization

Alternative names

Cach2, Cacn2, Cacnl1a1, Cchl1a1, Cacna1c, Voltage-dependent L-type calcium channel subunit alpha-1C, MELC-CC, Mouse brain class C, Voltage-gated calcium channel subunit alpha Cav1.2, MBC

swissprot:Q01815 entrezGene:12288

Other research areas