CACNB2
Function
Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370).
Involvement in disease
Brugada syndrome 4
BRGDA4
A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.
None
The gene represented in this entry may be involved in disease pathogenesis.
Post-translational modifications
Regulated through phosphorylation at Thr-554 by CaMK2D.
Sequence Similarities
Belongs to the calcium channel beta subunit family.
Tissue Specificity
Expressed in all tissues.
Cellular localization
- Cell membrane
- Sarcolemma
- Peripheral membrane protein
- Cytoplasmic side
Alternative names
CACNLB2, MYSB, CACNB2, Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2, Lambert-Eaton myasthenic syndrome antigen B