Cadherin-4
Domain
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
Tissue Specificity
Expressed mainly in brain but also found in other tissues.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
Cadherin-4, Retinal cadherin, R-CAD, R-cadherin, CDH4