Caf1-55
Developmental stage
Highest level during early embryogenesis and then decreases in larvae, pupae and adults.
Function
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2.
Sequence Similarities
Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
Cellular localization
- Nucleus
Alternative names
Caf1, CG4236, Caf1-55, Chromatin assembly factor 1 p55 subunit, CAF-1 p55 subunit, CAF-1, Nucleosome-remodeling factor 55 kDa subunit, NURF-55