CALCB
Function
CALCB/CGRP2 is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed:1318039, PubMed:9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (PubMed:3492492).
Sequence Similarities
Belongs to the calcitonin family.
Tissue Specificity
Expressed in spinal cord, pituitary and thalamus.
Cellular localization
- Secreted
Alternative names
CALC2, CALCB, Calcitonin gene-related peptide 2, CGRP2, Beta-type CGRP, Calcitonin gene-related peptide II, Beta-CGRP, CGRP-II