Calcium/calmodulin-dependent protein kinase II inhibitor 1
Function
Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (PubMed:28642476). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (PubMed:33746041). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (PubMed:31327268).
Sequence Similarities
Belongs to the CAMK2N family.
Tissue Specificity
Expressed in the brain (at protein level) (PubMed:17350603). Expressed in cardiomyocytes but not cardiac fibroblasts (at protein level) (PubMed:33746041).
Cellular localization
- Synapse
- Cell projection
- Dendrite
- Postsynaptic density
Alternative names
Calcium/calmodulin-dependent protein kinase II inhibitor 1, calcium/calmodulin-dependent protein kinase II inhibitor alpha, mCaMKIINalpha, Camk2n1