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Calcitonin receptor/CT-R

Function

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

Isoform 2

Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase (PubMed:7476993). Does not undergo receptor internalization following ligand binding (PubMed:7476993).

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein

Alternative names

  • Calcitonin receptor
  • CT-R
  • CALCR

Target type

Proteins

Molecular weight

55329Da