CALHM2
Function
Pore-forming subunit of Ca(2+) homeostasis modulator channels. Mediates ATP release from astrocytes and ATP-induced Ca(2+) influx in microglia thus regulating neuronal ATP and Ca(2+) homeostasis, synaptic transmission and neuroinflammatory response. May form intercellular gap junctions. The gating mechanism remains unknown.
Sequence Similarities
Belongs to the CALHM family.
Tissue Specificity
Placenta.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
FAM26B, CALHM2, Calcium homeostasis modulator protein 2, Protein FAM26B