CALHM6
Function
Pore-forming subunit of an ATP-permeable channel (By similarity). In response to pathogen-derived and proinflammatory stimuli, relocates from intracellular compartments to NK-dendritic cell and NK-macrophage immune synapses where it mediates ATP efflux and NK cell activation involved in antimicrobial and antitumor responses (By similarity). May assemble to form gap junction channel-like structures with gating and ion conductance likely regulated by membrane lipids and voltage rather than by extracellular calcium levels (PubMed:32374262).
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the CALHM family.
Tissue Specificity
Placenta.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Recruited at immune synapses in response to pathogen-derived and proinflammatory stimuli.
Alternative names
C6orf187, FAM26F, CALHM6, Calcium homeostasis modulator protein 6, Protein FAM26F