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CALM1

Domain

The N-terminal and C-terminal lobes of CALM bind to the C-terminus of KCNQ1 in a clamp-like conformation. Binding of CALM C-terminus to KCNQ1 is calcium-independent but is essential for assembly of the structure. Binding of CALM N-terminus to KCNQ1 is calcium-dependent and regulates electrophysiological activity of the channel (PubMed:25441029). The C-lobe interacts with KCNN4 channels in a calcium-independent manner, whereas the N-lobe interacts with the S4-S5 linker of KCNN4 in a calcium-dependent manner playing a role as calcium sensor and gating the channel (PubMed:29724949).

Function

Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335).

(Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity.

(Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity.

Involvement in disease

Ventricular tachycardia, catecholaminergic polymorphic, 4

CPVT4

An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. CPVT4 inheritance is autosomal dominant.

None

The disease is caused by variants affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4.

Long QT syndrome 14

LQT14

A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.

None

The disease is caused by variants affecting the gene represented in this entry.

Post-translational modifications

Ubiquitination results in a strongly decreased activity.

Phosphorylation results in a decreased activity.

Sequence Similarities

Belongs to the calmodulin family.

Cellular localization

Alternative names

CALM, CAM, CAM1, CALM1, Calmodulin-1

swissprot:P0DP23 swissprot:Q9BJF5 omim:114180 omim:114182 omim:114183 swissprot:114180 swissprot:P0DP24 swissprot:P0DP25 swissprot:P62158 entrezGene:801 entrezGene:805 entrezGene:808