CALM3

Function

Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:31454269). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425).

(Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity.

Involvement in disease

Ventricular tachycardia, catecholaminergic polymorphic, 6

CPVT6

An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. CPVT6 inheritance is autosomal dominant.

None

The disease may be caused by variants affecting the gene represented in this entry.

Long QT syndrome 16

LQT16

An autosomal dominant form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.

None

The disease is caused by variants affecting the gene represented in this entry.

Post-translational modifications

Ubiquitination results in a strongly decreased activity.

Phosphorylation results in a decreased activity.

Sequence Similarities

Belongs to the calmodulin family.

Cellular localization

• Cytoplasm
• Cytoskeleton
• Spindle
• Cytoplasm
• Cytoskeleton
• Spindle pole
• Cytoplasm
• Cytoskeleton
• Microtubule organizing center
• Centrosome
• Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.

Alternative names

CALML2, CAM3, CAMC, CAMIII, CALM3, Calmodulin-3

Database links

swissprot:P0DP25 swissprot:P0DP24 entrezGene:808 entrezGene:805 entrezGene:801 swissprot:Q9BJF5 swissprot:P62158 swissprot:P0DP23 swissprot:114180 omim:114182 omim:114180 omim:114183