CALN1

Domain

The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.

Function

Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning.

Tissue specificity

Brain specific.

Cellular localization

• Golgi apparatus
• Trans-Golgi network membrane
• Single-pass type IV membrane protein
• Cytoplasm
• Perinuclear region
• Cell membrane
• Single-pass type IV membrane protein

Alternative names

• Calcium-binding protein 8
• CaBP8
• Calneuron I
• Calneuron-1
• CABP8
• CALN1

Database links

• entrezGene:83698
• omim:607176
• swissprot:Q9BXU9

Target type

Proteins

Molecular weight

29324Da