CALN1
Domain
The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.
Function
Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning.
Tissue Specificity
Brain specific.
Cellular localization
- Golgi apparatus
- trans-Golgi network membrane
- Single-pass type IV membrane protein
- Cytoplasm
- Perinuclear region
- Cell membrane
- Single-pass type IV membrane protein
Alternative names
CABP8, CALN1, Calcium-binding protein 8, CaBP8, Calneuron I, Calneuron-1