CALR3
Domain
Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity).
The interaction with glycans occurs through a binding site in the globular lectin domain.
The zinc binding sites are localized to the N-domain.
Function
During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.
Sequence Similarities
Belongs to the calreticulin family.
Tissue Specificity
Testis specific.
Cellular localization
- Endoplasmic reticulum lumen
Alternative names
CRT2, CALR3, Calreticulin-3, Calreticulin-2, Calsperin