Calsequestrin-2

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:3427023). Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.

Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity.

N-glycosylated.

Belongs to the calsequestrin family.

Detected in heart muscle (at protein level).

• Sarcoplasmic reticulum lumen
• This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells.

Calsequestrin-2, CASQ2

• entrezGene:483134
• swissprot:P12637

Proteins

Neuroscience

47417Da