CALU

Function

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).

Sequence similarities

Belongs to the CREC family.

Tissue specificity

Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.

Cellular localization

• Endoplasmic reticulum membrane
• Golgi apparatus
• Secreted
• Melanosome
• Sarcoplasmic reticulum lumen
• Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Alternative names

• Calumenin
• Crocalbin
• IEF SSP 9302
• CALU

Database links

• entrezGene:813
• omim:603420
• swissprot:O43852

Target type

Proteins

Primary research area

Oncology

Molecular weight

37107Da