CALU

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).

Belongs to the CREC family.

Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.

• Endoplasmic reticulum membrane
• Golgi apparatus
• Secreted
• Melanosome
• Sarcoplasmic reticulum lumen
• Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Calumenin, Crocalbin, IEF SSP 9302, CALU

• entrezGene:813
• omim:603420
• swissprot:O43852

Proteins

Oncology

37107Da