CAMK1G
Domain
The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
Function
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).
Post-translational modifications
May be prenylated on Cys-473.
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Tissue Specificity
Mainly expressed in brain with small amounts in skeletal muscles, kidney, spleen and liver. Strongly expressed in forebrain neocortex, striatum and limbic system.
Cellular localization
- Cytoplasm
- Golgi apparatus membrane
- Peripheral membrane protein
- Cell membrane
- Peripheral membrane protein
Alternative names
CLICK3, VWS1, CAMK1G, Calcium/calmodulin-dependent protein kinase type 1G, CaM kinase I gamma, CaMK-like CREB kinase III, CaM kinase IG, CaM-KI gamma, CaMKI gamma, CaMKIG, CLICK III