cAMP-responsive element modulator
Function
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).
Isoform 6
May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
Post-translational modifications
Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
Stimulated by phosphorylation. Phosphorylated on Ser-116 by TSSK4 in vitro.
Sequence Similarities
Belongs to the bZIP family.
Tissue Specificity
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Cellular localization
- Nucleus
- Isoform 6
- Cytoplasm
- Nucleus
Alternative names
cAMP-responsive element modulator, Inducible cAMP early repressor, ICER, CREM