Camp
Developmental stage
Expressed in the adult and in the embryo where it is detected at 12-18 dpc.
Function
Antimicrobial protein that is an integral component of the innate immune system (By similarity). Binds to bacterial lipopolysaccharides (LPS) (By similarity).
Cathelin-related antimicrobial peptide
Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.
Post-translational modifications
Proteolytically cleaved by cathepsin CTSG.
Sequence Similarities
Belongs to the cathelicidin family.
Tissue Specificity
Expressed in granulocytes (at protein level) (PubMed:9148921). High expression in bone marrow and small intestine (PubMed:8706928, PubMed:9148921). Expressed in testis, spleen, stomach, and intestine (PubMed:9148921). Very low expression found in heart, lung and skeletal muscle (PubMed:9148921). No expression in brain, kidney or liver (PubMed:9148921).
Cellular localization
- Secreted
- Vesicle
- Stored as pro-peptide in granules and phagolysosomes of neutrophils.
Alternative names
Cnlp, Cramp, 24.1, Y10A, Cathelicidin antimicrobial peptide, Cathelin-like protein, CLP