CAPN10

Function

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.

Involvement in disease

Type 2 diabetes mellitus 1

T2D1

A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

None

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Sequence Similarities

Belongs to the peptidase C2 family.

Tissue Specificity

Detected in primary skeletal muscle cells (at protein level). Ubiquitous.

Alternative names

KIAA1845, CAPN10, Calpain-10, Calcium-activated neutral proteinase 10, CANP 10

Database links

swissprot:Q9HC96 omim:605286 genbank:NP_075571.1 entrezGene:11132