CAPN6
Function
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).
Sequence Similarities
Belongs to the peptidase C2 family.
Tissue Specificity
Expressed only in placenta.
Cellular localization
- Cytoplasm
- Perinuclear region
- Cytoplasm
- Cytoskeleton
- Spindle
- During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.
Alternative names
CALPM, CANPX, CAPN6, Calpain-6, Calpain-like protease X-linked, Calpamodulin, CalpM