Carbonic anhydrase 3
Developmental stage
At 6 weeks gestation, transcripts accumulate at low levels in the somites and at high levels throughout the notochord. As gestation continues, CA3 becomes abundant in all developing muscle masses and continues at high to moderate levels in the notochord.
Function
Reversible hydration of carbon dioxide.
Post-translational modifications
S-thiolated both by thiol-disulfide exchange with glutathione disulfide and by oxyradical-initiated S-thiolation with reduced glutathione.
S-glutathionylated in hepatocytes under oxidative stress.
Sequence Similarities
Belongs to the alpha-carbonic anhydrase family.
Tissue Specificity
Muscle specific.
Cellular localization
- Cytoplasm
Alternative names
Carbonic anhydrase 3, Carbonate dehydratase III, Carbonic anhydrase III, CA-III, CA3