CARD19
Function
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.
Tissue Specificity
Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.
Cellular localization
- Isoform 1
- Nucleus
- Coexpression with BCL10 induced translocation from nucleus to cytosol.
- Isoform 2
- Endoplasmic reticulum membrane
- Single-pass membrane protein
- Mitochondrion membrane
- Single-pass membrane protein
Alternative names
C9orf89, CARD19, Caspase recruitment domain-containing protein 19, Bcl10-interacting CARD protein, BinCARD