Casein kinase I isoform alpha phospho T321

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity).

Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation.

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

• Cytoplasm
• Cytoplasm
• Cytoskeleton
• Microtubule organizing center
• Centrosome
• Chromosome
• Centromere
• Kinetochore
• Nucleus speckle
• Cytoplasm
• Cytoskeleton
• Cilium basal body
• Cytoplasm
• Cytoskeleton
• Spindle
• Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688).

Casein kinase I isoform alpha, CKI-alpha, CK1, CSNK1A1

• swissprot:P48729

Proteins

Oncology

38915Da