CASP12
Function
May function as a negative regulator of inflammatory responses and innate immunity. May reduce cytokine release in response to bacterial lipopolysaccharide during infection. Reduces activation of NF-kappa-B in response to TNF (PubMed:15129283). May lack protease activity (Probable).
Sequence Similarities
Belongs to the peptidase C14A family.
Tissue Specificity
Widely expressed, with highest levels in lung.
Alternative names
UNQ9415/PRO34398, CASP12, Inactive caspase-12, CASP-12