CASP8AP2

Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.

• Cytoplasm
• Nucleus
• Nucleus
• PML body
• Mitochondrion
• Exported from the nucleus to the mitochondria upon FAS activation.

FLASH, KIAA1315, RIP25, CASP8AP2, CASP8-associated protein 2, FLICE-associated huge protein

• entrezGene:9994
• omim:606880
• swissprot:Q9UKL3

Proteins

Epigenetics

222658Da