CASS4
Function
Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading.
Post-translational modifications
Phosphorylated on tyrosines by SRC.
Sequence Similarities
Belongs to the CAS family.
Tissue Specificity
Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cell junction
- Focal adhesion
Alternative names
C20orf32, HEFL, CASS4, Cas scaffolding protein family member 4, HEF-like protein, HEF1-EFS-p130Cas-like protein, HEPL