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Function

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (PubMed:12782676). Has also been implicated in tumor invasion and metastasis (By similarity).

Sequence similarities

Belongs to the peptidase C1 family.

Tissue specificity

Expressed in thyroid epithelial cells.

Cellular localization

  • Lysosome
  • Melanosome
  • Secreted
  • Extracellular space
  • Apical cell membrane
  • Peripheral membrane protein
  • Extracellular side
  • Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.

Alternative names

Cathepsin B, Cathepsin B1, Ctsb

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

37280Da

We found 9 products in 3 categories

Primary Antibodies

Assay Kits

Reactive species

Detection method

Proteins & Peptides

Species of origin