CATB_MOUSE
Function
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (PubMed:12782676). Has also been implicated in tumor invasion and metastasis (By similarity).
Sequence Similarities
Belongs to the peptidase C1 family.
Tissue Specificity
Expressed in thyroid epithelial cells.
Cellular localization
- Lysosome
- Melanosome
- Secreted
- Extracellular space
- Apical cell membrane
- Peripheral membrane protein
- Extracellular side
- Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.
Alternative names
Cathepsin B, Cathepsin B1, Ctsb