CATSPER4
Function
Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
Sequence Similarities
Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
Tissue Specificity
Testis-specific.
Cellular localization
- Cell projection
- Cilium
- Flagellum membrane
- Multi-pass membrane protein
- Specifically located in the principal piece of the sperm tail.
Alternative names
Cation channel sperm-associated protein 4, CatSper4, CATSPER4