CAVIN2
Domain
The leucine-zipper domain is essential for its localization in the caveolae.
Function
Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).
Post-translational modifications
Phosphorylated on Ser residues.
Sequence Similarities
Belongs to the CAVIN family.
Tissue Specificity
Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
Cellular localization
- Cytoplasm
- Cytosol
- Membrane
- Caveola
- Localizes in the caveolae in a caveolin-dependent manner.
Alternative names
SDPR, CAVIN2, Caveolae-associated protein 2, Cavin-2, PS-p68, Phosphatidylserine-binding protein, Serum deprivation-response protein