CAVIN3
Domain
The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1.
Function
Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).
Post-translational modifications
In vitro, phosphorylated by PRKCD.
Sequence Similarities
Belongs to the CAVIN family.
Tissue Specificity
Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Strongly expressed in mammary and epithelial cells.
Cellular localization
- Cytoplasm
- Membrane
- Caveola
- Cytoplasm
- Cytosol
- Localizes in the caveolae in a caveolin-dependent manner.
Alternative names
PRKCDBP, SRBC, CAVIN3, Caveolae-associated protein 3, Cavin-3, Protein kinase C delta-binding protein, Serum deprivation response factor-related gene product that binds to C-kinase, hSRBC