CAVIN4

The coiled coil domain (residues 44-77) is essential for membrane-targeting in cardiomyocytes.

Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105).

Belongs to the CAVIN family.

• Cytoplasm
• Myofibril
• Sarcomere
• Cytoplasm
• Cytoplasm
• Cytosol
• Cell membrane
• Sarcolemma
• Membrane
• Caveola
• Cell membrane
• In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm. Localizes in the caveolae in a caveolin-dependent manner.

MURC, CAVIN4, Caveolae-associated protein 4, Muscle-related coiled-coil protein, Muscle-restricted coiled-coil protein

• entrezGene:347273
• swissprot:Q5BKX8

Proteins

41899Da