CBLL1
Domain
The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids.
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755).
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Phosphorylated on tyrosine residues.
Sequence Similarities
Belongs to the Hakai family.
Cellular localization
- Nucleus speckle
- Nucleus
- Nucleoplasm
- Cytoplasm
- Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.
Alternative names
HAKAI, RNF188, CBLL1, E3 ubiquitin-protein ligase Hakai, Casitas B-lineage lymphoma-transforming sequence-like protein 1, RING finger protein 188, RING-type E3 ubiquitin transferase Hakai, c-Cbl-like protein 1