CBR4

Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19000905). As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508).

Lipid metabolism; fatty acid biosynthesis.

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Detected in liver and kidney (at protein level) (PubMed:19000905). Displays the highest expression in neuronal and muscle tissues (PubMed:25203508).

• Mitochondrion matrix

SDR45C1, CBR4, 3-oxoacyl-[acyl-carrier-protein] reductase, 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit, Carbonyl reductase family member 4, Quinone reductase CBR4, Short chain dehydrogenase/reductase family 45C member 1, KAR beta subunit

• entrezGene:84869
• swissprot:Q8N4T8

Proteins

25301Da