CBX8
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Cellular localization
- Nucleus
Alternative names
PC3, RC1, CBX8, Chromobox protein homolog 8, Polycomb 3 homolog, Rectachrome 1, Pc3, hPc3