CCDC51

Pore-forming subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)) (PubMed:31435016). Together with ATP-binding subunit ABCB8/MITOSUR of the mitoK(ATP) channel, mediates ATP-dependent K(+) currents across the mitochondrial inner membrane (PubMed:31435016). An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume (PubMed:31435016).

Isoform 1: Widely expressed (PubMed:31435016). Isoform 2: Expression is barely detectable (PubMed:31435016).

• Mitochondrion inner membrane
• Multi-pass membrane protein
• Isoform 1
• Mitochondrion inner membrane
• Multi-pass membrane protein

MITOK, CCDC51, Mitochondrial potassium channel, Coiled-coil domain-containing protein 51

• entrezGene:79714
• swissprot:Q96ER9

Proteins

45811Da