CCDC6

Domain

The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation.

Involvement in disease

A chromosomal aberration involving CCDC6 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.

Tissue Specificity

Ubiquitously expressed.

Cellular localization

• Cytoplasm
• Cytoplasm
• Cytoskeleton
• May be a cytoskeletal protein.

Alternative names

D10S170, TST1, CCDC6, Coiled-coil domain-containing protein 6, Papillary thyroid carcinoma-encoded protein, Protein H4

Database links

swissprot:Q16204 omim:164761 omim:601985 swissprot:P07949 entrezGene:8030 entrezGene:5979

Other research areas

• Immuno-oncology