CCDC88B
Function
Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099).
Sequence Similarities
Belongs to the CCDC88 family.
Tissue Specificity
Expressed in endothelium (at protein level) (PubMed:21289099). Expressed in NK cells (at protein level) (PubMed:25762780).
Cellular localization
- Membrane
- Peripheral membrane protein
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Endoplasmic reticulum
- Golgi apparatus
- Cytoplasm
Alternative names
BRLZ, CCDC88B, Coiled-coil domain-containing protein 88B, Brain leucine zipper domain-containing protein, Gipie, Hook-related protein 3, HkRP3