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CCK1-R
Function
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
- Cholecystokinin receptor type A
- CCK-A receptor
- CCK-AR
- Cholecystokinin-1 receptor
- CCK1-R
- CCKRA
- CCKAR
Database links
Target type
Proteins
Molecular weight
47841Da