CCL17
GeneName
CCL17
Summary
CCL17, also known as TARC or thymus and activation regulated chemokine, is an 11 kDa secreted protein that plays a pivotal role in immune responses. It is primarily expressed in the extracellular region and is involved in chemokine activity, mediating cell-cell signalling and chemotaxis. CCL17 attracts various immune cells, particularly T cells, to sites of inflammation, thereby influencing the inflammatory response and contributing to the regulation of immune cell trafficking.
Importance
CCL17 is relevant to: - Allergic responses and asthma due to its role in recruiting Th2 cells and eosinophils. - Autoimmune diseases, as it is involved in the migration of immune cells to inflamed tissues. - Cancer immunology, where it may affect the tumour microenvironment by modulating immune cell infiltration. - Infectious diseases, given its function in directing immune responses towards pathogens.
Top Products
For researchers investigating CCL17, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-TARC/CCL17 antibody (ab182793), which has garnered 19 citations, highlighting its reliability in the field. This antibody is particularly effective for immunohistochemistry (IHC) and western blotting (WB), making it a versatile choice for various experimental needs. Additionally, we offer the recombinant antibody, Anti-TARC/CCL17 antibody [EPR15861] (ab195044). This monoclonal antibody is validated for IHC and provides the batch-to-batch consistency that researchers often require. With 4 citations, it is also gaining traction among scientists studying this important chemokine. Together, these antibodies provide robust options for CCL17 research. The Recombinant Human TARC/CCL17 Protein ELISA Kit (ab283903) is an excellent option for researchers looking to measure CCL17 in their experiments.
Abcam Product Citation Summary
The data indicates that CCL17 is being investigated in the context of human clear cell renal cell carcinoma, particularly focusing on its role in cancer prognosis. The use of immunohistochemistry suggests a detailed examination of CCL17 expression in tumour tissues.
Abcam Product Citation Table
Function
Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes (PubMed:8702936, PubMed:9169480). Acts by binding to CCR4 at T-cell surface (PubMed:10540332, PubMed:9169480). Mediates GM-CSF/CSF2-driven pain and inflammation (PubMed:27525438). In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation (By similarity). Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (By similarity).
Sequence Similarities
Belongs to the intercrine beta (chemokine CC) family.
Tissue Specificity
Constitutively expressed in thymus. Detected at lower levels in the lung, colon and small intestine (PubMed:8702936). Expressed in stimulated peripheral blood mononuclear cells, but not in resting cells (PubMed:8702936).
Cellular localization
- Secreted
Alternative names
SCYA17, TARC, CCL17, C-C motif chemokine 17, CC chemokine TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine
Database links
swissprot:Q92583 omim:601520 entrezGene:6361
Other research areas
- Immuno-oncology