MCP1

Function

Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690).

Post-translational modifications

Processing at the N-terminus can regulate receptor and target cell selectivity (PubMed:8627182). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (PubMed:8627182).

N-Glycosylated.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Tissue specificity

Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level) (PubMed:23765988). Expressed in monocytes (PubMed:2513477).

Cellular localization

• Secreted

Alternative names

• C-C motif chemokine 2
• HC11
• Monocyte chemoattractant protein 1
• Monocyte chemotactic and activating factor
• Monocyte chemotactic protein 1
• Monocyte secretory protein JE
• Small-inducible cytokine A2
• MCAF
• MCP-1
• MCP1
• SCYA2
• CCL2

Database links

• entrezGene:6347
• omim:158105
• swissprot:P13500

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

• Cardiovascular
• Immuno-oncology
• Neuroscience

Molecular weight

11025Da