CCL25

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Belongs to the intercrine beta (chemokine CC) family.

Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.

• Secreted

SCYA25, TECK, CCL25, C-C motif chemokine 25, Chemokine TECK, Small-inducible cytokine A25, Thymus-expressed chemokine

• entrezGene:6370
• omim:602565
• swissprot:O15444

Proteins

Immunology & Infectious Disease

16609Da