CCL28
Function
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
Sequence Similarities
Belongs to the intercrine beta (chemokine CC) family.
Tissue Specificity
Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.
Cellular localization
- Secreted
Alternative names
SCYA28, CCL28, C-C motif chemokine 28, Mucosae-associated epithelial chemokine, Protein CCK1, Small-inducible cytokine A28, MEC