Ccl3

Function

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).

Sequence Similarities

Belongs to the intercrine beta (chemokine CC) family.

Tissue Specificity

Expressed in lung, spleen, and pancreas.

Cellular localization

• Secreted

Alternative names

Mip1a, Scya3, Ccl3, C-C motif chemokine 3, Heparin-binding chemotaxis protein, L2G25B, Macrophage inflammatory protein 1-alpha, SIS-alpha, Small-inducible cytokine A3, TY-5, MIP-1-alpha

Database links

swissprot:P10855 entrezGene:20302

Other research areas

• Immuno-oncology
• Neuroscience