CCL4
GeneName
CCL4
Summary
CCL4, also known as ACT2, CCL-4, or Lag-1, is a 10 kDa chemokine that is secreted into the extracellular region and space. It plays a pivotal role in immune responses by binding to CCR1 and CCR5 chemokine receptors, facilitating chemokine-mediated signalling and cell adhesion. CCL4 is involved in various biological processes, including eosinophil chemotaxis, cell migration, and the inflammatory response, and it contributes to the antimicrobial humoral immune response through its activity as a cytokine. This protein is expressed in various immune cells and is crucial for cell-cell signalling and maintaining cell polarity.
Importance
CCL4 is relevant to: - The regulation of immune responses, particularly in the context of viral infections and inflammatory conditions. - The recruitment and activation of natural killer cells and eosinophils, which are essential for combating infections and modulating allergic responses. - The study of chemokine interactions and their implications in diseases such as cancer, where CCL4 may influence tumour microenvironments and immune evasion. - Understanding the mechanisms of cell migration and adhesion, which are vital in both normal physiological processes and pathological conditions.
Top Products
For researchers investigating CCL4, we highly recommend the top-selling recombinant antibody, Anti-CCL4/MIP-1 beta antibody [EP521Y] (ab45690). This antibody has been validated in knockout models, ensuring its reliability for your experiments. It is suitable for a variety of applications, including Western blotting (WB), ELISA, immunocytochemistry (ICC), and immunoprecipitation (IP), making it a versatile choice for your research needs. With 14 citations, this antibody is well-regarded in the scientific community, reflecting its effectiveness in CCL4 detection. The Recombinant Human CCL4/MIP-1 beta protein ELISA Kit (ab283444) is an excellent option for researchers looking to measure CCL4 in their experiments.
Abcam Product Citation Summary
The data indicates that the CCL4 target is being investigated in the context of human samples, particularly focusing on endothelial cell-derived extracellular vesicles and inflammatory markers. The use of ELISA suggests a quantitative approach to understanding the role of CCL4 in these biological processes.
Abcam Product Citation Table
Function
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Post-translational modifications
N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.
Sequence Similarities
Belongs to the intercrine beta (chemokine CC) family.
Cellular localization
- Secreted
Alternative names
LAG1, MIP1B, SCYA4, CCL4, C-C motif chemokine 4, G-26 T-lymphocyte-secreted protein, HC21, Lymphocyte activation gene 1 protein, MIP-1-beta(1-69), Macrophage inflammatory protein 1-beta, PAT 744, Protein H400, SIS-gamma, Small-inducible cytokine A4, T-cell activation protein 2, LAG-1, MIP-1-beta, ACT-2
Database links
swissprot:P13236 entrezGene:6351 omim:182284 omim:603782 omim:610757 swissprot:Q8NHW4 entrezGene:9560 entrezGene:388372
Other research areas
- Immuno-oncology
- Neuroscience