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RANTES

OverviewProducts

Function

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Tissue specificity

T-cell and macrophage specific.

Cellular localization

  • Secreted

Alternative names

  • C-C motif chemokine 5
  • MuRantes
  • SIS-delta
  • Small-inducible cytokine A5
  • T-cell-specific protein RANTES
  • Ccl5
  • Scya5

Database links

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

  • Immuno-oncology

Molecular weight

10071Da